Decidua and gestational trophoblastic neoplasia: a review

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Decidua and gestational trophoblastic neoplasia: a review Desidua ve gestasyonel neoplazi: derleme

The normal endometrium changes after implantation of an embryo. Decidua is the term for the endometrium during a pregnancy, which is formed under the influence of progesterone as the maternal part of the placenta. It has a histologically distinct appearance, displaying large polygonal decidual cells in the stroma. These are enlarged endometrial stromal cells, which resemble epithelium. Interact...

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Gestational trophoblastic neoplasia.

Trophoblastic neoplasms are a truly fascinating set of diseases that arise from a failed gestation. A molar pregnancy is an allograft of fetal tissue typically containing only paternal chromosomes that may invade the maternal decidua following a failed gestation that may have arisen up to decades earlier. Choriocarcinoma (CCA), the most common malignant form of trophoblastic disease, represente...

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Management of gestational trophoblastic neoplasia

It is just 100 years since Marchand [1] identified choriocarcinoma as a tumour arising from placental villous trophoblast. Earlier description of similar tumours failed to identify their tissue of origin. Gestational Trophoblastic Disease (GTD) is the terminological umbrella now used to span the spectrum of cellular proliferations ranging from villous forms of hydatiform mole through invasive m...

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Efficacy of combination therapy of Methotrexate and Vitamin A in low risk gestational trophoblastic neoplasia treatment

Introduction: Methotrexate as a single agent chemotherapy in most women with low risk gestational trophoblastic neoplasia (GTN) has been associated with high treatment rate. Combination of methotrexate with Vitamin A due to reduced number of chemotherapy regime courses is one of the treatment options for patients with low-risk GTN. Therefore, this study was performed with aim to determine the e...

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Efficacy of combination therapy of Methotrexate and Vitamin A in low risk gestational trophoblastic neoplasia treatment

Introduction: Methotrexate as a single agent chemotherapy in most women with low risk gestational trophoblastic neoplasia (GTN) has been associated with high treatment rate. Combination of methotrexate with Vitamin A due to reduced number of chemotherapy regime courses is one of the treatment options for patients with low-risk GTN. Therefore, this study was performed with aim to determine the e...

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ژورنال

عنوان ژورنال: Basic and Clinical Sciences

سال: 2013

ISSN: 1309-5102

DOI: 10.12808/bcs.v1i1.2